This issue is caused by the Windows 10 Anniversary update and can affect all versions of AutoCAD and AutoCAD based products. AutoCAD will eventually become responsive again but only after waiting 5-10 minutes.
Source: How to Stop AutoCAD from Freezing When … He can print using our plot marcro, but due to how we have our plotter set up, he needs to go … … It also freezes when he uses the plot icon or goes to file print. If you enter a value followed by xp, AutoCAD specifies the scale. By MetsoKyle, Main AutoCAD Drawing Management & Output. AutoCAD does not display, plot, or regenerate objects on frozen layers.